Keep your eyes on vitamin B3 news. Vitamin B3 also known as Nicotinamide (AKA Niacinamide) have been found to prevent Alzheimer’s pathology and improve memory in transgenic mice. Studies are on the way to find if the same effect is found in humans.
Nicotinamide decrease levels of phosphorylated tau which is one of the key neuropathological hallmarks of Alzheimer’s disease. Tau is involved in the formation of mircotubules which can be thought of as the train tracks (or key transportation system) along the length of the cell. Without it, both intracellular and extracellular communication can’t occur. It also increases the stability of this transportation system via other mechanisms, and works to increase p25, a protein which has been linked to improved learning and memory.
Phase 2 trials at UC Irvine have started, this phase is looking for patients who are in the early stages of alzheimer’s. Keep your eyes on phase 2 and 3 of these clinical trials
Vitamin B3 is easily found in meat, fish, beans, potatoes and cereals, comparable [to the mice] doses for humans are far higher than is found in one’s diet.
Investigators at UC Irvine are starting a phase 2 trial in humans by giving their subjects 1,500 mg twice a day. That is 3000 mg a day. Common multivitamins contain about 10mg only. The recommended daily dose is 16mg for men and 14mg for women.
Taking 1000mg a day or more could induce liver toxicity and other side effects, thus caution and more information on safety is needed.
Nicotinamide belongs to a class of compounds called HDAC inhibitors, which have been shown to protect the central nervous system in rodent models of Parkinson’s and Huntington’s diseases and amyotrophic lateral sclerosis. Clinical trials are underway to learn whether HDAC inhibitors help ALS and Huntington’s patients.
An observational prospective study conducted by Martha. C. Morris at Rush University showed that in their Chicago population of 3718 subjects that those who consumed more niacin (a precursor to nicotinamide) over a 5.5 yr period had substantially less cognitive decline. This same study showed in a smaller subset that those who consumed more niacin also had a 70% lower risk of Alzheimer’s disease.
Stay Informed
There seems to be enough promising results so far to warrant keeping a close watch on B3 research. Many people, including myself, would like to see their memory improved and would like to decrease their chances of getting Alzheimer’s.
What Is The Truth – Will It Be Known?
Due to the simplicity of this solution (i.e. over the counter vitamin that is not expensive or patentable) I hope that the research is not influenced in any way by large corporations that would rather patent a drug to make a profit.
The Best Things Are Simple (or Natural)
It is my observation and belief that MOST good and beneficial things in life are simple and found in nature. Most of the time, naturally occurring things and simplicity do miracles. This observations is true in many fields, from medicine, to wellness, to physics and math, computer science, and chemistry, etc… The best equations and solutions out there are simple, and esthetically appealing (pretty, just as is Nature).
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